Physical Activity Correlates With Neurological Impairment and Disability in Multiple SclerosisMotl, Robert W. PhD*; Snook, Erin M. MS*; Wynn, Daniel R. MD†; Vollmer, Timothy MD‡The Journal of Nervous and Mental Disease: June 2008 - Volume 196 - Issue 6 - p 492-495 doi: 10.1097/NMD.0b013e318177351b Brief Report Buy Abstract Author InformationAuthors Article MetricsMetrics This study examined the correlation of physical activity with neurological impairment and disability in persons with multiple sclerosis (MS). Eighty individuals with MS wore an accelerometer for 7 days and completed the Symptom Inventory (SI), Performance Scales (PS), and Expanded Disability Status Scale. There were large negative correlations between the accelerometer and SI (r = −0.56; ρ = −0.58) and Expanded Disability Status Scale (r = −0.60; ρ = −0.69) and a moderate negative correlation between the accelerometer and PS (r = −0.39; ρ = −0.48) indicating that physical activity was associated with reduced neurological impairment and disability. Such findings provide a preliminary basis for using an accelerometer and the SI and PS as outcome measures in large-scale prospective and experimental examinations of the effect of physical activity behavior on disability and dependence in MS. *Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, Illinois; †Consultants in Neurology Multiple Sclerosis Center, Northbrook, Illinois; and ‡Neuroimmunology Program, Barrow Neurological Institute, Phoenix, Arizona. Send reprint requests to Robert W. Motl, PhD, Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, 350 Freer Hall, 906 South Goodwin Ave., Urbana, IL 61801. E-mail: email@example.com. © 2008 Lippincott Williams & Wilkins, Inc.