Original ArticleCognitive Functioning in Depersonalization DisorderGuralnik, Orna PsyD*; Giesbrecht, Timo PhD*†; Knutelska, Margaret PhD*; Sirroff, Beth PsyD*; Simeon, Daphne MD*Author Information *Department of Psychiatry, Mount Sinai School of Medicine, New York City, New York; and †Department of Experimental Psychology, Maastricht University, Maastricht, the Netherlands. Supported in part by a NARSAD Young Investigator award to Dr. Guralnik, NIMH award MH-55582 to Dr. Simeon and a grant from the Netherlands Organization for Scientific Research (N.W.O., 446-06-010) to Dr. Giesbrecht. Send reprint requests to Dr. Simeon, Department of Psychiatry, Box #1230, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029. E-mail: [email protected]. The Journal of Nervous and Mental Disease: December 2007 - Volume 195 - Issue 12 - p 983-988 doi: 10.1097/NMD.0b013e31815c19cd Buy Metrics Abstract Depersonalization disorder (DPD) is a dissociative disorder characterized by a subjective sense of unreality and detachment, and has been associated with deficits in perception and short-term memory. In this study, 21 DPD and 17 healthy comparison participants free of psychiatric disorders were administered a comprehensive neuropsychologic battery. The groups did not differ in full-scale, verbal, and performance IQ (Wechsler Adult Intelligence Scale), in working memory (Paced Auditory Serial Addition Test), or in selective attention (Digit Span with Distracters). The DPD group performed significantly worse on immediate visual and verbal recall (Wechsler Memory Scale, Revised), but not on delayed recall. Dissociation severity was significantly correlated with processing slowness and distractibility. We conclude that DPD is associated with cognitive disruptions in early perceptual and attentional processes. © 2007 Lippincott Williams & Wilkins, Inc.