Original ArticleGender Differences in Young Adults With First-Episode Schizophrenia Spectrum Disorders at Baseline in the Danish OPUS StudyThorup, Anne MD*; Petersen, Lone MSc*; Jeppesen, Pia MD, PhD*; Ohlenschlæger, Johan MD†; Christensen, Torben MSc‡; Krarup, Gertrud MD‡; Jorgensen, Per MD‡; Nordentoft, Merete MD, PhD*Author Information *Department of Psychiatry, Bispebjerg Hospital, Copenhagen NV, Denmark; †Sct. Hans Hospital, Roskilde, Denmark; and ‡Psychiatric Hospital Risskov, Aarhus, Denmark. The OPUS trial was funded by the Danish Ministry of Health grant jr.nr. 96-0770-71; Danish Ministry of Social Affairs, Danish Medical Research Council grants jr.nr. 9601612 and 9900734; Copenhagen Hospital Corporation, Aarhus County; and The University of Copenhagen. This study was supported by the Worzner Foundation. Send reprint requests to Anne Thorup, Department of Psychiatry, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen NV, Denmark. E-mail: [email protected]. The Journal of Nervous and Mental Disease: May 2007 - Volume 195 - Issue 5 - p 396-405 doi: 10.1097/01.nmd.0000253784.59708.dd Buy Metrics Abstract Gender differences in age at first onset, duration of untreated psychosis, psychopathology, social functioning, and self-esteem were investigated in a group of 578 young adults with a first-episode schizophrenia spectrum disorder. The mean age at first-onset of symptoms, age at first contact, and duration of untreated psychosis were similar for men and women. Men had more severe negative symptoms, poorer premorbid functioning, and poorer social networks, whereas women had more severe hallucinations. More men than women were substance abusers, were unemployed, and lived alone. Women had poorer self-esteem than men, in spite of better scores in functioning. Premorbid social adjustment was significantly related to the level of negative symptoms and number of friends. Conclusion is that men and women with first-episode psychosis showed different psychopathological characteristics and different social functioning, which cannot be explained by older age of onset for women. Women make more suicide attempts and experience lower self-esteem in spite of better social functioning. © 2007 Lippincott Williams & Wilkins, Inc.