Original Article: PDF OnlyBRIEF COMMUNICATION: Sleep Induced by L-Tryptophan Effect of Dosages within the Normal Dietary IntakeHARTMANN, ERNEST M.D.1; SPINWEBER, CHERYL L. Ph.D.2 Author Information 1Sleep and Dream Laboratory, Boston State Hospital, and Tufts University School of Medicine. Send reprint requests to Dr. Hartmann, Boston State Hospital, Boston, Massachusetts 02124 2Naval Health Research Center, San Diego The Journal of Nervous and Mental Disease: August 1979 - Volume 167 - Issue 8 - p 497-499 Buy Abstract Previous results have demonstrated sleep-inducing effects of L-tryptophan in doses of 1 to 15 g at bedtime. The present laboratory study extends the dose-response curve downward, comparing doses of ¼ g, ½ g, and 1 g of L-tryptophan with placebo, in 15 mild insomniacs (subjects who reported sleep latencies of over 30 minutes). One gram of Ltryptophan significantly reduced sleep latency: the lower doses produced a trend in the same direction. Stage IV sleep was significantly increased by ¼ g of L-tryptophan. These results at low doses have interesting implications since the normal dietary intake of L-tryptophan is ½ g to 2 g per day. © Williams & Wilkins 1979. All Rights Reserved.