This study used a mixed method to test a model of demands on nurses. Factors were identified that affect demands, and a model was tested using structural equation modeling. Teamwork and expertise had significant effects on nurse-sensitive outcomes. Leadership was a strong determinant of stability and expertise. Workload was not a significant predictor of outcomes, but this is likely due to the difficulty in measuring nursing work. These results provide administrators with actionable recommendations that can be used to reduce the demands on nursing staff.