Lung Cancer Among Firefighters: Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies : Journal of Occupational and Environmental Medicine

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Lung Cancer Among Firefighters

Smoking-Adjusted Risk Estimates in a Pooled Analysis of Case-Control Studies

Bigert, Carolina MD, PhD; Gustavsson, Per MD, PhD; Straif, Kurt MD, PhD; Taeger, Dirk PhD; Pesch, Beate PhD; Kendzia, Benjamin MSc; Schüz, Joachim PhD; Stücker, Isabelle PhD; Guida, Florence PharmD; Brüske, Irene MD; Wichmann, Heinz-Erich PhD; Pesatori, Angela C. MD, PhD; Landi, Maria Teresa MD, PhD; Caporaso, Neil MD; Tse, Lap Ah PhD; Yu, Ignatius Tak-sun PhD; Siemiatycki, Jack PhD; Lavoué, Jérôme PhD; Richiardi, Lorenzo MD, PhD; Mirabelli, Dario MD; Simonato, Lorenzo MD; Jöckel, Karl-Heinz PhD; Ahrens, Wolfgang PhD; Pohlabeln, Hermann PhD; Tardón, Adonina PhD; Zaridze, David MD, PhD; Field, John K. PhD; ’t Mannetje, Andrea PhD; Pearce, Neil PhD; McLaughlin, John PhD; Demers, Paul PhD; Szeszenia-Dabrowska, Neonila PhD; Lissowska, Jolanta PhD; Rudnai, Peter MD; Fabianova, Eleonora MD, PhD; Stanescu Dumitru, Rodica PhD; Bencko, Vladimir MD, PhD; Foretova, Lenka MD, PhD; Janout, Vladimir PhD; Boffetta, Paolo MD, MPH; Peters, Susan PhD; Vermeulen, Roel PhD; Kromhout, Hans PhD; Brüning, Thomas MD, PhD; Olsson, Ann C. PhD

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Journal of Occupational and Environmental Medicine 58(11):p 1137-1143, November 2016. | DOI: 10.1097/JOM.0000000000000878



The aim of this study was to explore lung cancer risk among firefighters, with adjustment for smoking.


We used pooled information from the SYNERGY project including 14 case-control studies conducted in Europe, Canada, New Zealand, and China, with lifetime work histories and smoking habits for 14,748 cases of lung cancer and 17,543 controls. We estimated odds ratios by unconditional logistic regression with adjustment for smoking and having ever been employed in a job known to present an excess risk of lung cancer.


There was no increased lung cancer risk overall or by specific cell type among firefighters (n = 190), neither before nor after smoking adjustment. We observed no significant exposure-response relationship in terms of work duration.


We found no evidence of an excess lung cancer risk related to occupational exposure as a firefighter.

Copyright © 2016 by the American College of Occupational and Environmental Medicine

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