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Letters to the Editor

Reply: Endotoxin, a Possible Agent in the Causation of Parkinson’s Disease

Li, Abby A. PhD; Mink, Pamela J. PhD, MPH; McIntosh, Laura J. PhD, DABT; Teta, M Jane DrPH, MPH; Finley, Brent PhD, DABT

Author Information
Journal of Occupational and Environmental Medicine: July 2006 - Volume 48 - Issue 7 - p 655-656
doi: 10.1097/01.jom.0000222587.99012.e5
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Authors’ Response: We thank Lange et al for their comments related to our paper, “Evaluation of Epidemiologic and Animal Data Associating Pesticides With Parkinson’s Disease.”1 Lange et al outline the literature indicating that endotoxins may represent an agricultural risk factor for Parkinson’s Disease (PD) not covered in our review article. Although this letter raises the important point that future research should explore a variety of agricultural risk factors for PD, we limited the scope of our review to analytical epidemiology studies and whole animal studies using systemic exposure to pesticides. Nonetheless, based on the lack of causal evidence present in the pesticide literature at this time, it seems justified to support research on other possible alternatives, including endotoxins.

Abby A. Li, PhD

Health Sciences Practice

Exponent, Inc.

San Francisco, California

Pamela J. Mink, PhD, MPH

Health Sciences Practice

Exponent, Inc.

Washington DC

Laura J. McIntosh, PhD, DABT

Health Sciences Practice

Exponent, Inc.

San Francisco, California

M. Jane Teta, DrPH, MPH

Health Sciences Practice

Exponent, Inc.

New York, NY

Brent Finley, PhD, DABT

ChemRisk

Santa Rosa, California

Reference

1. Li AA, Mink PJ, McIntosh LJ, Teta MJ, Finley B. Evaluation of epidemiologic and animal data associating pesticides with Parkinson’s disease. J Occup Environ Med. 2005;10:1059–87.
©2006The American College of Occupational and Environmental Medicine