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Prenatal Exposure to Perfluorinated Compounds Affects Birth Weight Through GSTM1 Polymorphism

Kwon, Eun Jin BS; Shin, Joon Soo BS; Kim, Byung Mi PhD; Shah-Kulkarni, Surabhi MS; Park, Hyesook MD, PhD; Kho, Young lim PhD; Park, Eun Ae MD, PhD; Kim, Young Ju MD, PhD; Ha, Eun Hee MD, PhD

Journal of Occupational and Environmental Medicine: June 2016 - Volume 58 - Issue 6 - p e198–e205
doi: 10.1097/JOM.0000000000000739
Original Articles

Objective: The aim of this study was to investigate the effect of genetic polymorphisms on the association of prenatal exposure to perfluorinated compounds (PFCs) with birth weight.

Methods: We analyzed the level of eight PFCs in cord blood and two genetic polymorphisms in maternal blood of 268 subjects.

Results: Concentrations of perfluorooctanoic acid, perfluorooctane sulfonate, perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) showed significant association with a decrease in birth weight (P < 0.05). In mothers with glutathione S-transferase M1 (GSTM1) null genotype, concentrations of PFNA, PFDA, and PFUnDA showed significantly negative association with birth weight (P < 0.05).

Conclusion: Our findings indicated that GSTM1 polymorphism might affect the association between exposure to PFCs and birth weight, suggesting the effect of genetic susceptibility on the relationship between prenatal PFCs exposure and birth outcomes.

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Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, South Korea (Ms Kwon, Drs Kim, Kulkarni, Park, Ha); Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, South Korea (Dr Park); Department of Obstetrics and Gynecology, School of Medicine, Ewha Womans University, Seoul, South Korea (Ms Kwon, Dr Kim); Department of Health, Environment & Safety, Eulji University, Seongnam, South Korea (Dr Kho); Cancer Policy Branch (Dr Kim), National Cancer Center, Goyang, South Korea; and Chicago Medical School (Mr Shin), Rosalind Franklin University of Medicine and Science, Lake County, Illinois.

Address correspondence to: Eun Hee Ha, MD, PhD, School of Medicine, Ewha Womans University, Seoul 158-710, South Korea (

This research was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education Science and Technology (NRF-2013R1A2A2A01068120).

The authors declare no conflicts of interest.

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Copyright © 2016 by the American College of Occupational and Environmental Medicine