Université de Caen Normandie (Dr Pons, Dr Boulanger, Ms Busson, Ms Renier, Dr Lebailly), France; French National Institute of Health and Medical Research (Inserm); Unité Mixte de Recherche (UMR) 1086 ANTICIPE (Dr Pons, Dr Boulanger, Dr Tual, Ms Busson, Ms Renier, Ms Perrier, Ms Levêque-Morlais, Dr Lebailly), Caen, France; Comprehensive Cancer Centrer François Baclesse (Dr Boulanger, Dr Tual, Ms Perrier, Ms Levêque-Morlais, Dr Lebailly) Caen, France; Central Agricultural Social Insurance (CCMSA), Echelon National Santé Sécurité au Travail, Bobigny (Dr Marcotullio), France; French National Institute of Health and Medical Research (Inserm), Population Health Research Center, Team EPICENE Unité Mixte de Recherche (UMR) 1219, Université de Bordeaux (Dr Baldi), France; CHU de Bordeaux, Pôle de Santé Publique, Service Santé Travail Environnement (Dr Baldi), Bordeaux, France.
Address correspondence to: Romain Pons, PhD, INSERM UMR 1086 “ANTICIPE”, Comprehensive Cancer Center François Baclesse, Avenue du Général Harris, 14 076 Caen Cedex 5, France ([email protected]).
Clinical significance: We reported prolonged time to pregnancy in women working on farm and involved in specific agricultural activities. Pesticides applied on grapes and insecticides on cattle but also nightwork and vibrations could be associated with subfertility in this female farm workforce.
Funding sources: The authors thank the Agence française pour la biodivesité (ONEMA – Ecophyto 2018 plan) for funding PhD thesis of R. Pons. This work was supported by Ligue Contre le Cancer (Nationale and Comités du Calvados, de l’Orne, de la Manche, du Maine-et-Loire et de Paris), Mutualité Sociale Agricole (caisse centrale et caisses des Alpes du Nord, de l’Alsace, de Bourgogne-Franche Comté, des Côtes Normandes, de Gironde, de Loire Atlantique–Vendée, de Midi Pyrénées Nord, de la Picardie), Fondation de France, Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (within the call for projects 2005, 2006, and 2010 of the program «Environnement Santé Travail» of ANSES, with funding from ONEMA in support of the Ecophyto 2018 plan), Institut National du Cancer [InCA8422], Association pour la Recherche sur le Cancer [ARC02–010], Institut National de Médecine Agricole, Centre François Baclesse and Ministère de l’Enseignement Supérieur et de la Recherche.
Conflicts of Interest: None declared.
Ethical Considerations & Disclosure(s): The study protocol was reviewed and approved by the Advisory Committee on Information Processing in Material Research in the Field of Health (Comité consultatif sur le traitement de l’information en matière de recherche; number: 01.148) and the French data protection authority (Commission Nationale de l’Informatique et des Libertés; number: 05.1292).
Contributors: P.L. and R.P. supervised the study. R.P. performed analyses and wrote the manuscript's draft. P.L., I.B., M.B., S.T., and S.P. provided methodological help. All authors critically reviewed the manuscript.
Supplemental digital contents are available for this article. Direct URL citation appears in the printed text and is provided in the HTML and PDF versions of this article on the journal's Web site (www.joem.org).
