Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, California (Dr Omidakhsh, Dr Ritz, Dr Coleman, Dr Heck); Danish Cancer Society Research Center, Copenhagen, Denmark (Dr Hansen); Department of Environmental Health Sciences, School of Public Health, University of California, Los Angeles, California (Dr Ritz); Department of Ophthalmology, David Geffen School of Medicine, University of California, Los Angeles, California (Dr Coleman); Department of Preventive Medicine, University of Southern California, Los Angeles, California (Dr McKean-Cowdin); Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark (Dr Olsen).
Address correspondence to: Negar Omidakhsh, PhD, Southern California NIOSH Education and Research Center, University of California Los Angeles, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772 ([email protected]).
This work was supported by the Occupational Epidemiology Research Training Program of the Southern California NIOSH Education and Research Center, Grant Agreement Number T42OH008412 from the Centers for Disease Control and Prevention (CDC). Its contents are solely the responsibility of the authors and do not necessarily represent the official view of the CDC. This work was also partially supported by the NIH/NIEHS (RO3ES021643, R21ES019986). Dr Heck was supported by a grant from Alex's Lemonade Stand Foundation (grant #17-01882).
The authors report no conflicts of interest.
Ethics approval for the current study was obtained by the University of California, Los Angeles institutional review board as well as the Danish Data Protection Agency. As the study did not include any primary data collection, but rather utilized anonymized registry data, patient consent was not required.
Clinical Significance: Retinoblastoma is the most common eye tumor affecting children and may be associated with parental occupational exposures before conception or in utero. Our study identifies several potential paternal occupational risk factors for retinoblastoma based on job title. Studies on childhood cancer are rare and additional research is needed.
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