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Arsenic Exposure and Incident Hypertension of Adult Residents Living in Rural Areas Along the Yangtze River, Anhui, China

Zhong, Qi, MD; Zhang, Chi, MM; Zhang, Qian, MD; Jiang, Chun-Xiao, MM; Qin, Qi-Rong, MD; Chen, Jian, MM; Liang, Ling, MD; Huang, Fen, MD, PhD

Journal of Occupational and Environmental Medicine: April 2019 - Volume 61 - Issue 4 - p 271–277
doi: 10.1097/JOM.0000000000001511

Objective: As a widespread toxic metal, arsenic had potential effect for hypertensive. We evaluated the association between urinary arsenic and the incidence of hypertension in adult residents along the Yangtze River of China.

Methods: We conducted the study of 1358 adults 18 to 74 years of age from Chizhou, Maanshan, and Tongling of Anhui province, who participated in the baseline study in 2014 to 2015. Inductively coupled plasma optical emission spectrometry was used to measure urinary as of residents, and follow-up extended through 2016 to 2017.

Results: We identified 275 hypertension events. The hazard ratios (HRs) of highest quartile arsenic compared with lowest quartile was 1.49 for hypertension events (95% confidence interval [CI] = 1.05 to 2.12), and HRs (≥P20 vs <P20) was 1.37 (95% CI = 1.02 to 1.84).

Conclusions: Higher level of arsenic exposure might play a role in increasing the incidence of hypertension.

Department of Epidemiology and Biostatistics, School of Public Health (Dr Zhong, Ms Zhang, Dr Zhang, Mr Jiang, Dr Liang, Dr Huang); Ma′anshan Center for Disease Control and Prevention, Ma′anshan (Dr Qin, Mr Chen); and Experimental Center Platform for Physical and Chemical (Dr Huang), Anhui Medical University, Hefei, Anhui, P.R. China.

Address correspondence to: Fen Huang, MD, PhD, Department of Epidemiology and Biostatistics Statistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan Districts, Hefei, Anhui 230032, P.R. China (

Q.Z. and C.Z. have contributed equally to this current research.

Funding: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from the National Natural Science Foundation of China (No. 81373071).

Clinical Significance: To control the blood pressure in the normal range, the hypertensive living in areas with higher levels of arsenic not only take antihypertensive medication, but also reduce the consumption of food contaminated with arsenic. And the regulation on minimizing the exposure to arsenic may be considered in policies of environmental health and intervention programs.

Huang, Zhong, C. Zhang, Q. Zhang, Jiang, Qin, Chen, and Liang have no relationships/conditions/circumstances that present potential conflict of interest.

The JOEM editorial board and planners have no financial interest related to this research.

Copyright © 2019 by the American College of Occupational and Environmental Medicine