The aim of this study was to explore the association between telomere length and metabolizing enzyme gene polymorphisms and environmental factors in omethoate-exposed workers.
The gene–environment interactions were analyzed with generalized linear model method.
The relative telomere lengths in the individuals with GSTM1-deletion were longer than that in non-deletion genotype in the control group (P = 0.011); the relative telomere lengths with GG+AG genotypes in GSTP1 rs1695 were longer than that of AA genotype in the exposure group (P = 0.039). The interaction between the GG+AG genotypes in GSTP1 rs1695 and smoking exposure had significant effect on telomere length (P < 0.05).
The prolongation of relative telomere length in omethoate-exposed workers was associated with GSTM1-deletion, GG+AG genotypes, and interactions of GG+AG genotypes and smoking factor.
Department of Occupational Health and Occupational Diseases (Drs W. Wang, H. Zhang, Duan, Feng, T. Wang, P. Wang, Ding, Yao); Clinical Department, Zhengzhou Institute of Occupational Health (Drs S. Liu, Li, J. Liu, Tang, Niu, Y. Zhang, Li); Department of Epidemiology and Biostatistics (Dr Yang), College of Public Health, Zhengzhou University, Zhengzhou, China.
Address correspondence to: Yongli Yang, PhD, Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China (email@example.com).
The statement of clinical significance: The research results help to understand the mechanism of telomere damage induced by toxicants and might be used for screening effective susceptible biomarkers and early prevention of high risk population.
Authors’ contributions: W.W. contributed to the conception of the study. H.Z. performed the data analyses and wrote the manuscript. X.D., X.F., T.W., P.W., M.D., S.L., L.L., J.L., L.T., X.N., Y.Z., and G.L. performed the experiments and collected samples. W.Y. and Y.Y. helped perform the analysis with constructive discussions.
Ethics: This study was conducted with the consent of the Zhengzhou University Life Science and Ethics Review Committee. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Funding: We are also thankful for the support from the Programs for Science and Technology Development of Zhengzhou (131PPTGG376) and the Outstanding Youth Grant of Zhengzhou University (1521329035).
Conflict of interest: None declared.