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Effects of Genetic Polymorphism on Susceptibility to Nephrotoxic Properties of BTEXs Compounds

Neghab, Masoud PhD; Nourozi, Mohamad Amin PhD; Shahtaheri, Seyed Jamaleddin PhD; Mansoori, Yaser PhD; Bazzaz, Javad Tavakkoly PhD; Nedjat, Saharnaz PhD

Journal of Occupational and Environmental Medicine: August 2018 - Volume 60 - Issue 8 - p e377–e382
doi: 10.1097/JOM.0000000000001364
ORIGINAL ARTICLES
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Objective: The aim of this study was to ascertain whether genetic polymorphism affects susceptibility of individuals to nephrotoxic potentials of benzene, toluene, ethyl-benzene, and xylenes (BTEXs).

Methods: Fifty BTEXs exposed workers with one or more abnormal parameter of kidney function and 232 referent subjects, with similar exposure history, free from any abnormal kidney parameters were investigated. Atmospheric concentrations of BTEXs were measured. In addition, genetic polymorphisms were determined by multiplex polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP).

Results: The frequencies of GSTP1 Ile-Val/Val-Val, null GSTT1, and null GSTT1/GSTM1 genotypes and mean values of blood urea nitrogen and plasma creatinine were significantly higher, while average glomerular filtration rate was significantly lower in cases than in referent subjects.

Conclusion: These findings indicate that individuals carrying null GSTT1 or null GSTT1/GSTM1 are more susceptible to nephrotoxic properties of BTEXs compounds.

Research Center for Health Sciences, Institute of Health, Department of Occupational Health Engineering, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran (Dr Neghab); Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran (Dr Nourozi); Department of Occupational Health Engineering, School of Public Health, Institute for Environmental Research, Tehran University of Medical Sciences, Tehran, Iran (Dr Shahtaheri); Non-communicable Diseases Research Center, Department of Medical Genetics, Fasa University of Medical Sciences, Fasa, Iran (Dr Mansoori); Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran (Dr Bazzaz); and Department of Epidemiology and Biostatistics, School of Public Health, Knowledge Utilization Research Center (KURC), Tehran University of Medical Sciences, Tehran, Iran (Dr Nedjat).

Address correspondence to: Seyed Jamaleddin Shahtaheri, PhD, Tehran University of Medical Sciences, Tehran 1417613151, Iran (shahtaheri@tums.ac.ir).

The authors declare that there is no conflict of interests.

Copyright © 2018 by the American College of Occupational and Environmental Medicine