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Transcriptional Pathways Altered in Response to Vibration in a Model of Hand-Arm Vibration Syndrome

Waugh, Stacey MS; Kashon, Michael L. PhD; Li, Shengqiao PhD; Miller, Gerome R. BS; Johnson, Claud BS; Krajnak, Kristine PhD

Journal of Occupational and Environmental Medicine: April 2016 - Volume 58 - Issue 4 - p 344–350
doi: 10.1097/JOM.0000000000000705

Objective: The aim of this study was to use an established model of vibration-induced injury to assess frequency-dependent changes in transcript expression in skin, artery, and nerve tissues.

Methods: Transcript expression in tissues from control and vibration-exposed rats (4 h/day for 10 days at 62.5, 125, or 250 Hz; 49 m/s2, rms) was measured. Transcripts affected by vibration were used in bioinformatics analyses to identify molecular- and disease-related pathways associated with exposure to vibration.

Results: Analyses revealed that cancer-related pathways showed frequency-dependent changes in activation or inhibition. Most notably, the breast-related cancer-1 pathway was affected. Other pathways associated with breast cancer type 1 susceptibility protein related signaling, or associated with cancer and cell cycle/cell survivability were also affected.

Conclusion: Occupational exposure to vibration may result in DNA damage and alterations in cell signaling pathways that have significant effects on cellular division.

Engineering Controls and Technology Branch and Biostatistics and Epidemiology Branch (Waugh, Miller, Johnson, Dr Krajnak), and National Institute for Occupational Safety and Health, Morgantown, West Virginia (Drs Kashon, Li).

Address correspondence to: Kristine Krajnak, PhD, 1095 Willowdale Rd., MS2023, Morgantown, WV 26505 (

This work was internally funded by the National Institute for Occupational Safety and Health (NIOSH). The content of this publication does not necessarily reflect the views or policies of the NIOSH.

There are no conflicts of interest, or additional funding sources to declare.

Copyright © 2016 by the American College of Occupational and Environmental Medicine