The course of lung function in community members exposed to World Trade Center (WTC) dust and fumes remains undefined. We studied longitudinal spirometry among patients in the WTC Environmental Health Center (WTCEHC) treatment program.
Observational study of 946 WTCEHC patients with repeated spirometry measures analyzed on the population as a whole and stratified by smoking status, initial spirometry pattern, and WTC-related exposure category.
Improvement in forced vital capacity (54.4 mL/yr; 95% confidence interval, 45.0 to 63.8) and forced expiratory volume in 1 second (36.8 mL/yr; 95% confidence interval, 29.3 to 44.3) was noted for the population as a whole. Heavy smokers did not improve. Spirometry changes differed depending on initial spirometry pattern and exposure category.
These data demonstrate spirometry improvement in select populations suggesting reversibility in airway injury and reinforcing the importance of continued treatment.
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From the Departments of Population Health (Drs Liu, Cheng, Shao, Marmor, and Qian), Environmental Medicine (Drs Liu, Cheng, Shao, Marmor, and Reibman, and Ms Qian), and Medicine (Drs Berger, Turetz, Kazeros, Parsia, Goldring, Caplan-Shaw, Fernandez-Beros, Marmor, and Reibman), New York University School of Medicine.
Address correspondence to: Joan Reibman, MD, 550 1st Ave, Room NB7N24, New York University School of Medicine, New York, NY 10016. (firstname.lastname@example.org).
This study was funded by American Red Cross Liberty Disaster Relief Fund, City of New York, Centers for Disease Control and Prevention (CDC)–National Institute for Occupational Services and Health (NIOSH) 1E11OH009630, CDC-NIOSH contracts 200–2011-39391 and 200–2011-39397, National Institute of Environmental Health Sciences (NIEHS) center grant ES00260, CDC Broad Agency Announcement (BAA) 200–2011-39413, and National Institutes of Health–NIEHS T32 ES07267.
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Disclosure: The authors have no potential conflicts of interest.