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Relationship Between Several Markers and Presence of Metabolic Syndrome or Components of the Metabolic Syndrome in Japanese Workers

Kawada, Tomoyuki MD

Journal of Occupational and Environmental Medicine: August 2012 - Volume 54 - Issue 8 - p 984–988
doi: 10.1097/JOM.0b013e31825335ae
Original Articles

Background: The reported associations between metabolic syndrome (MetS) and systemic vascular inflammation/insulin resistance prompted the author to determine the predictive ability of markers for MetS in the occupational field.

Methods: The study was performed in 3460 working men aged 30 to 64 years. The author measured the serum levels of high-sensitivity C-reactive protein and insulin as potential key biomarkers of MetS.

Results: Multivariate analysis revealed significant associations between the presence of MetS and the log-transformed value of serum insulin and log-transformed value of serum C-reactive protein, with odds ratios of 29.4 (95% confidence interval, 18.0 to 48.2; P < 0.001) and 1.87 (95% confidence interval, 1.47 to 2.38; P < 0.001) of these two markers, respectively, for the presence of MetS.

Conclusion: Elevated serum levels of insulin were found to be strongly associated with MetS in this cross-sectional study.

From the Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan.

Address correspondence to: Tomoyuki Kawada, Department of Hygiene and Public Health, Nippon Medical School, 1–1-5 Sendagi, Bukyo-Ku, Tokyo 113–8602, Japan (

This study was supported by Grant-in-Aid for Scientific Research (C) (20590616) and also by the Department of Hygiene and Public Health, Nippon Medical School.

The author declares no conflict of interest.

©2012The American College of Occupational and Environmental Medicine