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Predictors of the Development of Metabolic Syndrome in Male Workers: A 3-year Follow-Up Study

Kawada, Tomoyuki MD, PhD

Journal of Occupational and Environmental Medicine: March 2012 - Volume 54 - Issue 3 - p 292–295
doi: 10.1097/JOM.0b013e3182492070
ORIGINAL ARTICLES: CME Available for this Article at

Background: Risk assessment for the development of metabolic syndrome (MetS) is an important strategy for prevention.

Methods: A 3-year follow-up study was conducted for 1677 Japanese workers not fulfilling the diagnostic criteria for MetS. Age and the five components of MetS, serum uric acid, serum insulin, lifestyle factors, and occupational position were used for the analysis.

Results: The odds ratios (95% confidence intervals) for MetS development among the subjects who initially had one or two MetS components were 3.1 (1.8 to 5.3) and 7.8 (4.5 to 13.5), respectively. When the MetS components were used as independent variables, the odds ratios (95% confidence intervals) of each component were significant for MetS development. Occupational position did not present significance.

Conclusion: Presence of each component of MetS as well as the number of MetS components are powerful predictors of the development of MetS after 3 years.

From the Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan.

Address correspondence to: Tomoyuki Kawada, MD, PhD, Department of Hygiene and Public Health, Nippon Medical School, 1-1-5 Sendagi, Bukyo-Ku, Tokyo 113–8602, Japan. (

Author Kawada has no financial disclosures related to this research. This work was supported by Grant-in-Aid for Scientific Research (C) (20590616).

The JOEM Editorial Board and planners have no financial interest related to this research.

©2012The American College of Occupational and Environmental Medicine