Occupational Exposures and Cancer of the Larynx—Systematic Review and Meta-analysis : Journal of Occupational and Environmental Medicine

Secondary Logo

Journal Logo

Advanced Search
ORIGINAL ARTICLES

Occupational Exposures and Cancer of the Larynx—Systematic Review and Meta-analysis

Paget-Bailly, Sophie MS; Cyr, Diane MS; Luce, Danièle PhD

Author Information

From Inserm, Center for Research in Epidemiology and Population Health, UMRS 1018, Occupational and Environmental Determinants of Health; and Versailles Saint-Quentin University, UMRS 1018, Villejuif, France.

Address correspondence to: Danièle Luce, MS, Inserm UMRS 1018, CESP, Team 11, 15–16 Ave Paul Vaillant Couturier, F-94807 Villejuif, France ([email protected]).

The authors declare that they have no conflict of interest.

Supplemental digital content is available for this article. Direct URL citation appears in the printed text and is provided in the HTML and PDF versions of this article on the journal's Web site (www.joem.org).

Journal of Occupational and Environmental Medicine 54(1):p 71-84, January 2012. | DOI: 10.1097/JOM.0b013e31823c1343

Abstract

Objective: 

To review epidemiologic data on occupational exposures and laryngeal cancer.

Methods: 

We performed a systematic literature search and a series of meta-analyses for agents with at least 10 available studies with homogenous exposure.

Results: 

We analyzed 99 publications. Significantly increased meta-relative risks (meta-RRs) were obtained considering exposure to polycyclic aromatic hydrocarbons (meta-RR 1.29; 95% confidence interval [CI] 1.10 to 1.52), engine exhaust (meta-RR 1.17; 95% CI 1.05 to 1.30), textile dust (meta-RR 1.41; 95% CI 1.09 to 1.83), and working in the rubber industry (meta-RR 1.39; 95% CI 1.13 to 1.71). Exposures to wood dust, formaldehyde, and cement dust were not significantly associated with laryngeal cancer. In regards of the epidemiologic available data, we could not conclude on the role of solvents.

Conclusion: 

Further studies should overcome past limitations in terms of exposure characterization, adjustment for confounding, and sample size.

©2012The American College of Occupational and Environmental Medicine

Full Text Access for Subscribers:

Not a Subscriber?

Buy
Request Permissions
Become a Society Member

You can read the full text of this article if you:

Access through Ovid