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Association Between IL-1A Single Nucleotide Polymorphisms and Chronic Beryllium Disease and Beryllium Sensitization

McCanlies, Erin C. PhD; Yucesoy, Berran PhD; Mnatsakanova, Anna MS; Slaven, James E. MS; Andrew, Michael PhD; Frye, Bonnie L. BS; Schuler, Christine R. PhD; Kreiss, Kathleen MD; Weston, Ainsley PhD

Journal of Occupational and Environmental Medicine: July 2010 - Volume 52 - Issue 7 - p 680-684
doi: 10.1097/JOM.0b013e3181e48ec8
Original Articles

Objective: To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS).

Methods: Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5′ nuclease polymerase chain reaction assay. Logistic regression was used to evaluate the association between IL SNPs, CBD, and BeS, adjusting for plant-site and HLA-DPB1Glu69 in additive, dominant, and recessive inheritance models.

Results: IL-1A-1142, IL-1A-3769, and IL-1A-4697 were significantly associated with CBD in both the additive and dominant models compared to individuals with BeS or the nonsensitized.

Conclusions: These results indicate that genetic variations in the IL-1A gene may play a role in the development of CBD but not BeS.

From the Health Effects Laboratory Division (Dr McCanlies, Dr Yucesoy, Dr Mnatsakanova, Mr Slaven, Dr Andrew, Ms Frye); and Division of Respiratory Disease Studies (Dr Schuler, Dr Kreiss, Dr Weston), National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Morgantown, WVa.

CME Available for this Article at

The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the National Institute for Occupational Safety and Health.

Erin McCanlies and coauthors Berran Yucesoy, Anna Mnatsakanova, James E. Slaven, Michael E. Andrew, Bonnie L. Frye, Christine R. Schuler, Kathleen Kreiss, and Ainsley Weston have no financial interest related to this research.

The JOEM Editorial Board and planners have no financial interest related to this research.

Address correspondence to: Erin McCanlies, PhD, NIOSH, CDC, MS-L4050, 1095 Willowdale Road, Morgantown, WV 26505; E-mail:

©2010The American College of Occupational and Environmental Medicine