To evaluate further elevated mortality risks from respiratory system cancer (RSC) and lymphatic and hematopoietic tissue cancers (LHTC) in a cohort of 1466 male workers employed full-time in pharmaceutical production.
We computed standardized mortality ratios, and in nested case-control studies of RSC and LHTC, evaluated mortality risks by plant exposures with adjustment for potential confounding factors.
Subjects with potential plant exposure had no elevated RSC risk and a statistically significant LHTC excess. The case-control study found many RSC risks reduced with adjustment for smoking, and LHTC risks increased with increasing levels of average exposure to dimethyl-formamide.
RSC mortality risks decreased, and we found limited evidence that positive confounding by smoking may explain some remaining excess risks. For LHTC, increased mortality risks and exposure-response patterns in the case-control study may indicate a possible workplace association.
From the Center for Occupational Biostatistics and Epidemiology (Dr Youk, Dr Buchanich, Dr Marsh, Mr Cunningham), Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa; and Division of Environmental and Occupational Health Sciences (Dr Esmen), School of Public Health, University of Illinois at Chicago, Chicago, Ill.
Address correspondence to: Ada O. Youk, PhD, A412 Crabtree Hall, Center for Occupational Biostatistics and Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261; E-mail: email@example.com.