The principal objective of this work was to evaluate the association between the risk of hepatocellular carcinoma (HCC) and various occupations.
This case-control study, conducted during 2000 to 2003 in four French hospitals, included 125 men younger than 75 years with incident HCC and 142 men as control subjects.
An association with HCC was observed for machinery fitters and machine assemblers (odds ratio [OR] = 4.4 [1.0–19.0], eight exposed cases and three exposed controls). A higher percentage of cases than controls were metal machinists (OR = 2.2 [0.8–5.8], 14 exposed cases and 10 exposed controls), although the difference was not statistically significant. These associations were strongest for subjects with duration of employment greater than 20 years.
Our findings suggest an association between metal machining jobs and hepatocellular carcinoma, although we cannot rule out the possibility that it was observed by chance.
From the Inserm Unité 754-IFR 69 (Drs Ferrand and Stücker, Ms Cénée), Villejuif, France; Inserm U775 (Drs Laurent-Puig and Loriot) Paris, France; Hôpital de Nancy-Brabois (Dr Bronovicky) Vandoeuvre les Nancy, France; Hôpital Beaujon (Dr Degos) Clichy, France; Hôpital Jean Verdier (Dr Trinchet) Bondy, France; and Hôpital de Bicêtre (Dr Pelletier) Le Kremlin-Bicêtre, France.
Address correspondence to: Isabelle Stücker, PhD, INSERM, Unité 754-IFR 69, 16 avenue Paul Vaillant-Couturier, 94807 Villejuif Cédex, France; E-mail: firstname.lastname@example.org.