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Hepatocellular Carcinoma and Occupation in Men: A Case-Control Study

Ferrand, Jean-François MD; Cénée, Sylvie MSc; Laurent-Puig, Pierre MD, PhD; Loriot, Marie-Anne MD, PhD; Trinchet, Jean Claude MD, PhD; Degos, Françoise MD, PhD; Bronovicky, Jean-Pierre MD, PhD; Pelletier, Gilles MD, PhD; Stücker, Isabelle PhD

Journal of Occupational and Environmental Medicine: February 2008 - Volume 50 - Issue 2 - p 212-220
doi: 10.1097/JOM.0b013e31815d88e2
Original Articles

Objective: The principal objective of this work was to evaluate the association between the risk of hepatocellular carcinoma (HCC) and various occupations.

Methods: This case-control study, conducted during 2000 to 2003 in four French hospitals, included 125 men younger than 75 years with incident HCC and 142 men as control subjects.

Results: An association with HCC was observed for machinery fitters and machine assemblers (odds ratio [OR] = 4.4 [1.0–19.0], eight exposed cases and three exposed controls). A higher percentage of cases than controls were metal machinists (OR = 2.2 [0.8–5.8], 14 exposed cases and 10 exposed controls), although the difference was not statistically significant. These associations were strongest for subjects with duration of employment greater than 20 years.

Conclusions: Our findings suggest an association between metal machining jobs and hepatocellular carcinoma, although we cannot rule out the possibility that it was observed by chance.

From the Inserm Unité 754-IFR 69 (Drs Ferrand and Stücker, Ms Cénée), Villejuif, France; Inserm U775 (Drs Laurent-Puig and Loriot) Paris, France; Hôpital de Nancy-Brabois (Dr Bronovicky) Vandoeuvre les Nancy, France; Hôpital Beaujon (Dr Degos) Clichy, France; Hôpital Jean Verdier (Dr Trinchet) Bondy, France; and Hôpital de Bicêtre (Dr Pelletier) Le Kremlin-Bicêtre, France.

Address correspondence to: Isabelle Stücker, PhD, INSERM, Unité 754-IFR 69, 16 avenue Paul Vaillant-Couturier, 94807 Villejuif Cédex, France; E-mail:

©2008The American College of Occupational and Environmental Medicine