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Associations Between Exposure to Polycyclic Aromatic Hydrocarbons and Temporal Change of Urinary 1-Hydroxypyrene Levels in Taiwanese Coke-Oven Workers

Lin, Ying-Chu PhD; Pan, Chih-Hong MSc; Chen, Chiou-Jong PhD; Wu, Kuen-Yuh PhD; Chang-Chien, Guo-Ping PhD; Ho, Chi-Kung PhD; Wu, Trong-Neng PhD; Chuang, Hong-Yi MD, PhD; Kuo, Hsien-Wen PhD; Wu, Ming-Tsang MD, PhD

Journal of Occupational and Environmental Medicine: September 2006 - Volume 48 - Issue 9 - p 930-936
doi: 10.1097/01.jom.0000226974.91335.5b
Original Articles

Objectives: Our aim is to analyze the association between polycyclic aromatic hydrocarbon (PAH) exposure and the temporal change of urinary 1-hydroxypyrene (1-OHP).

Methods: Two personal air samples, eight spot urine samples, and questionnaires were used to collect PAH exposure, urinary 1-OHP, demographic data, and environmental pollutants.

Results: Topside-oven workers had significantly higher levels of PAH exposure and 1-OHP than side-oven workers. Urinary 1-OHP was a biomarker for PAH exposure. In topside-oven workers, the trend of 1-OHP increased sharply and reached the top in the sixth day after work and declined dramatically on days off. In side-oven workers, such a trend was not found, and those who smoked showed a slight increase in urinary 1-OHP levels on days off.

Conclusions: We suggest that the pattern of temporal change of urinary 1-OHP levels is different between topside-oven and side-oven workers.

From the Graduate Institute of Dental Science (Mr Lin) and the Graduate Institute of Occupational Safety and Health (Dr Ho, Dr T-N Wu, Dr Chuang, Dr M-T Wu), Kaohsiung Medical University, Kaohsiung, Taiwan; the Institute of Occupational Safety and Health (Mr Pan, Dr Chen), Council of Labor Affairs, Taipei, Taiwan; the Division of Environmental Health and Occupational Medicine (Dr K-Y Wu), National Health Research Institute, Kaohsiung, Taiwan; the Department of Chemical Engineering (Dr Chang-Chien), Cheng Shiu University, Kaohsiung, Taiwan; and the Departments of Occupational Medicine and Family Medicine (Dr Kuo) and the Graduate Institute of Environmental Health (Dr M-T Wu), China Medical University & Hospital, Taichung, Taiwan.

Address correspondence to: Ming-Tsang Wu, MD, PhD, Departments of Occupational Medicine and Family Medicine, and Graduate Institute of Environmental Health, China Medical University & Hospital, 2, Yuh-Der Road, Taichung 404, Taiwan; E-mail:

©2006The American College of Occupational and Environmental Medicine