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Early Pneumotoxic Effects After Oral Administration of 1,2-Dichloroethane

Salovsky, Pencho MD, PhD, DSc; Shopova, Veneta MD, PhD; Dancheva, Violeta MD; Yordanov, Yordan MD; Marinov, Evlogi MD, PhD

Journal of Occupational and Environmental Medicine: May 2002 - Volume 44 - Issue 5 - p 475-480
ORIGINAL ARTICLES
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Early biochemical and histological changes in rat lungs were investigated after oral administration of 136 mg/kg 1,2-dichloroethane in oleum solution. The experiment was performed using 80 male Wistar rats. Bronchoalveolar lavage fluid and lung homogenate were examined on posttreatment days 1, 5, 15, and 30. In bronchoalveolar lavage fluid, the activities of lactate dehydrogenase, alkaline phosphatase, and acid phosphatase were elevated on day 1. The activities of superoxide dismutase, catalase, and glutathione peroxidase, and the content of malondialdehyde in lung homogenate, were also increased on day 1. The histological investigation indicated congestion, edema, and lung interstitial inflammatory changes. It was concluded that oral administration of 1,2-dichloroethane causes mild-to-moderate transitory toxic injury of the lung. Lipid peroxidation and the levels of key antioxidant enzymes are increased in the earliest posttreatment period.

From the Department of Disaster Medicine (Dr Salovsky, Dr Shopova, Dr Dancheva) and the Department of Pathology (Dr Yordanov, Dr Marinov), University of Medicine, Pleven, Bulgaria.

Address correspondence to: Dr Pencho Salovsky, Department of Disaster Medicine, University of Medicine, 1, Kliment Ohridski Str, Pleven 5800, Bulgaria; salovsky@yahoo.com.

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©2002The American College of Occupational and Environmental Medicine