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Genetic Polymorphisms of MnSOD, GSTM1, GSTT1, and OGG1 in Coal Workers’ Pneumoconiosis

Zhai, Rihong MD; Liu, Geoffrey MD, MS; Ge, Xianmin MD; Yang, Chaomin MD; Huang, Chuonhong MD; Wu, Chuanren MD; Christiani, David C. MD, MPH, MS

Journal of Occupational and Environmental Medicine: April 2002 - Volume 44 - Issue 4 - p 372-377
ORIGINAL ARTICLES
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Little is known about the genetic susceptibility to coal workers’ pneumoconiosis (CWP). We investigated the association between genetic polymorphisms of MnSOD, GSTM1, GSTT1, or OGG1 and susceptibility to CWP. The study population was composed of 259 Chinese retired coal miners who had similar dust exposure histories. Of these, there were 99 cases with International Labor Organization chest radiologic criteria for CWP and 160 controls (with no radiologic criteria for CWP). Individual dust exposure variables were estimated from work histories, and smoking information was obtained from interviews. Polymerase chain reaction-based techniques evaluated the genotypes of all study subjects. There were no differences in genotype frequency of MnSOD, GSTM1, GSTT1, and OGG1 between miners with CWP and miners without CWP, by logistic regression analysis. Cumulative dust exposures, but not genetic polymorphisms, were associated significantly with the presence of CWP. This study illustrates the complexity of factors that may contribute to the development of CWP.

From the Occupational Health Program, Department of Environmental Health, Harvard School of Public Health (Dr Zhai, Dr Liu, Dr Christiani); and the Division of Pneumoconiosis, Guangxi Institute of Occupational Health (Dr Yang, Dr Ge); the Division of Occupational Health, Guangxi Anti-epidemic and Health Center (Dr Huang); and the General Hospital of Heshan Coal Mine Company (Dr Wu); People’s Republic of China.

Address correspondence to: Dr. David C. Christiani, Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115; dchris@hohp.harvard.edu.

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