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Natural Rubber Latex:: Glove Use, Sensitization, and Airborne and Latent Dust Concentrations at a Denver Hospital

Page, Elena H. MD, MPH; Esswein, Eric J. MSPH; Petersen, Martin R. PhD; Lewis, Daniel M. PhD; Bledsoe, Toni A. MS

Journal of Occupational and Environmental Medicine: June 2000 - Volume 42 - Issue 6 - p 613-620
Original Articles

Exposure to natural rubber latex may cause immediate hypersensitivity reactions. Published latex sensitization prevalence rates range from 2.9% to 22% among health care workers, and from 0.12% to about 20% of occupationally unexposed populations. In this study, self-administered questionnaires addressed job and personal characteristics, glove use, and symptoms in two groups of hospital workers: those who regularly used latex gloves and those who did not. Serum was tested for latex-specific immunoglobulin E. Air, surface, and air-filter dust samples for natural rubber latex were collected. The prevalence of latex sensitization was 6.3% in the non-users and 6.1% in the latex glove users (P = 0.9); 81.3% of sensitized workers were atopic compared with 59.5% of non-sensitized workers (P < 0.05). Reporting of work-related hand dermatitis was more common in the latex glove users (23.4%) than in the non-users (4.9%), as were rhino-conjunctivitis (16.3% and 7.9%, respectively, [P < 0.01]), and hand urticaria (9.9% and 2.1%, respectively, [P < 0.01]). There was no significant difference in work-related symptoms between the sensitized and non-sensitized workers. Environmental concentrations of latex were higher in the work areas of the non-sensitized workers, but higher in the clinical than in the non-clinical areas. Occupational latex glove use was not a risk factor for sensitization.

From the Epidemic Intelligence Service (Dr Page), Division of Surveillance, Hazard Evaluations, and Field Studies (Dr Page, Mr Esswein, Dr Petersen); and the Health Effects Laboratory Division (Dr Lewis, Ms Bledsoe); National Institute for Occupational Safety and Health, and Epidemiology Program Office (Dr Page); Centers for Disease Control and Prevention, Cincinnati, Ohio.

Address correspondence to: Dr Elena H. Page, NIOSH, 4676 Columbia Parkway, MS R-10, Cincinnati, OH 45226-1998; email

© 2000 Lippincott Williams & Wilkins, Inc.