Original ArticlesBrain Cancer and Occupational Exposure to LeadCocco, Pierluigi MD; Dosemeci, Mustafa PhD; Heineman, Ellen F. PhDAuthor Information From the Institute of Occupational Medicine, University of Cagliari, Cagliari, Italy (Dr Cocco); and the Occupational Epidemiology Branch, National Cancer Institute, Bethesda, Md. (Dr Dosemeci, Dr Heineman). Address correspondence to: Mustafa Dosemeci, PhD, Occupational Epidemiology Branch, National Cancer Institute, 6130 Executive Boulevard, EPN Room 418, Bethesda, MD 20892. Journal of Occupational & Environmental Medicine: November 1998 - Volume 40 - Issue 11 - p 937-942 Buy Abstract A recent report in the literature suggested a link between occupational exposure to lead and brain cancer. To explore the hypothesis, we applied a job-exposure matrix for lead to the occupation and industry codes given on the death certificate of 27,060 brain cancer cases and 108,240 controls who died of non-malignant diseases in 24 US states in 1984-1992. Brain cancer risk increased by probability of exposure to lead among Caucasian men and women with high-level exposure, with a significant twofold excess among Caucasian men with high probability and high level of exposure to lead (odds ratio = 2.1; 95% confidence interval, 1.1-4.0). Risks were also elevated in the low- and medium-probability cells for African-American men with high-level exposure to lead. Trend by intensity level was statistically significant among African-American men (all probabilities combined). Although exposure assessment was based solely on the occupation and industry reported on the death certificate, these results add to other epidemiologic and experimental findings in lending some support to the hypothesis of an association between occupational exposure to lead and brain cancer risk. Analytic studies are warranted to further test this hypothesis. © Williams & Wilkins 1998. All Rights Reserved.