This study was to determine whether exposure to dimethylformamide (DMF) and acrylonitrile (ACN) separately or in combination, was associated with increased cancer incidence. Workers exposed to DMF and/or AON were observed from 1956 through 1984 for cancer incidence. The workers exposed to DMF but not AON showed significant excesses in incidence for buccal cavity and pharynx cancer and malignant melanoma. A significant excess of prostate cancer incidence was observed among workers exposed to DMF and AON. No dose-response relationships were observed between DMF or AON exposure and cancer incidence. The significant excesses in cancer incidence among employees exposed to DMF and/or AON could be due to statistical chance or other factors, such as tobacco and alcohol consumption. Further studies are warranted.
©1988 The American College of Occupational and Environmental Medicine