Chelatable Lead Body Burden (by Calcium-Disodium EDTA) and Blood Lead Concentration in Man

Abstract

The chelatable part of lead body burden was measured in 32 workers and seven office workers after an infusion test with CaNa₂EDTA. The workers had been exposed to lead at a lead and zinc processing unit for one to three, years (mean one year). There was good correlation (r=0.87) between blood lead and chelatable urinary lead excretion described by the equation y = 0.07·10^0.46·x. From this equation it can be predicted that the generally accepted limit value for chelatable urinary lead excretion, 0.42 µmol/mmol CaNa₂EDTA administered per 24 hours (3.1 µmol/24 hours or 650 µg/24 hours), corresponds to a blood lead concentration (PbB) of 1.7 µmol/l (or 35 µg/100 ml), which is lower than the commonly accepted limit value of 2.9 µmol/l (or 60 µg/100 ml) for occupationally lead-exposed persons. There was a better correlation between the chelatable lead excretion and the urinary ALA-excretion (r=0.45; p<0.001) than between PbB and the urinary ALA-excretion (r=0.26;p > 0.05).