Clinical InvestigationsEqui-MAC Concentrations of Halothane and Isoflurane Do Not Produce Similar Bispectral Index ValuesUmamaheswara Rao, Ganne S. MD; Ali, Zulfiqar MD; Ramamoorthy, Madhusudan MD; Patil, Jayaprakash MDAuthor Information Department of Neuroanaesthesia, National Institute of Mental Health and Neurosciences, Bangalore, India Statement of Financial Support and Conflict of Interest: The study has been performed only with institutional resources and no financial support has been received from any other source. The authors do not have any conflicts of interest in the material of the study. Reprints: Ganne S. Umamaheswara Rao, MD, Department of Neuroanaesthesia, National Institute of Mental Health and Neurosciences, Bangalore 560 029 India (e-mail: [email protected]; [email protected]). Received for publication October 29, 2006; accepted November 30, 2006 Journal of Neurosurgical Anesthesiology: April 2007 - Volume 19 - Issue 2 - p 93-96 doi: 10.1097/ANA.0b013e31803062f9 Buy Metrics Abstract Minimum alveolar concentration (MAC) has been traditionally used to measure the potency of an inhalational anesthetic agent. Recently, bispectral index (BIS) derived from the frontal cortical electroencephalogram has been used frequently for quantifying the hypnotic component of anesthesia. The present study was designed to examine the BIS values produced by equi-MAC concentrations of halothane and isoflurane. In 34 patients undergoing spinal surgery, BIS and spectral edge frequency (SEF95) were recorded at 3 different concentrations of halothane and isoflurane—namely 0.5, 0.75, and 1.0 MAC. The measurements were made both during wash-in and wash-out phases of the anesthetic agent. Eighteen patients received halothane and 16 received isoflurane. Heart rate, mean arterial pressure, oxygen saturation, and end tidal carbon dioxide pressure values were not different between the 2 groups at various MAC concentrations of the anesthetic agents. BIS and SEF95 values decreased significantly with increasing concentrations of both the anesthetic agents (P<0.001). At any given MAC concentration of the anesthetic, BIS and SEF95 values were significantly lower under isoflurane compared with halothane anesthesia both during wash-in and wash-out phases (P<0.001). For a given anesthetic agent, BIS values were comparable at equi-MAC concentrations during wash-in and wash-out phases. In conclusion, BIS values are significantly lower under isoflurane compared with halothane anesthesia at similar MAC concentrations. For a given anesthetic agent and a given MAC concentration, the BIS values are similar during wash-in and wash-out phases of anesthesia. © 2007 Lippincott Williams & Wilkins, Inc.