Clinical ReportsEffectiveness of an Intravascular Cooling Method Compared With a Conventional Cooling Technique in Neurologic PatientsHinz, José DEAA, MD*; Rosmus, Martin MD*; Popov, Aron MD†; Moerer, Onnen MD*; Frerichs, Inez MD, PhD‡; Quintel, Michael MD, PhD*Author Information *Department of Anaesthesiology, Emergency and Intensive Care Medicine †Department of Thoracic, Cardiovascular Surgery, University Göttingen ‡Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany Reprints: Dr José Hinz, DEAA, MD, Robert-Koch-Str. 40D-37075 Göttingen, Germany (e-mail: [email protected]). Received for publication October 1, 2006; accepted December 27, 2006 Journal of Neurosurgical Anesthesiology: April 2007 - Volume 19 - Issue 2 - p 130-135 doi: 10.1097/ANA.0b013e318032a208 Buy Metrics Abstract Fever is common among neurologic patients and is usually treated by antipyretic drugs and external cooling. An alternative method for temperature management may be an intravascular approach. The aim of the study was to compare the effectiveness and the therapeutic costs of this new method with conventional treatment in neurologic patients. Twenty-six patients who suffered from subarachnoid hemorrhage or traumatic brain injury with febrile episodes were included the study and were randomized into 2 different groups. In the “Conventional” group, fever was treated with antipyretic drugs and/or surface cooling techniques to achieve a body core temperature of 36.5°C. In the “CoolGard” group, patients were treated with an intravascular cooling catheter (Coolgard, Alsius, CA). We compared the effectiveness of these 2 approaches by calculating the mean deviation from 36.5°C during a 48-hour period (fever burden). We found a significant difference in the fever burden [CoolGard: −0.49 to 1.22 (median −0.06) °C vs. Conventional: 1.05-2.34 (median 1.41) °C, P<0.05]. Costs varied significantly between the CoolGard and the Conventional groups, with markedly higher daily costs in the CoolGard group [CoolGard: 15 to 140 US dollars (USD) (median 39 USD) vs. Conventional: 1 to 9 USD (median 5 USD), P<0.05]. The effectiveness of the intravascular cooling catheter is excellent compared with conventional cooling therapies. © 2007 Lippincott Williams & Wilkins, Inc.