Case ReportAwake Craniotomy with Dexmedetomidine in Pediatric PatientsArd, John*; Doyle, Werner†; Bekker, Alex* Author Information Departments of*Anesthesiology and†Neurosurgery, New York University Medical Center, New York, New York Address correspondence and reprint requests to Alex Bekker, MD, PhD, Department of Anesthesiology, New York University Medical, 550 First Avenue, New York, NY, 10016 (e-mail: [email protected]). Accepted for publication on February 11, 2003. Journal of Neurosurgical Anesthesiology 15(3):p 263-266, July 2003. Buy Abstract We present our experience with the use of dexmedetomidine, an α2 agonist, in two children undergoing awake craniotomy. General anesthesia with the laryngeal mask airway was used for parts of the procedure not requiring patient cooperation to reduce the duration of wakefulness and abolish the discomfort of surgical stimulation. Dexmedetomidine was used as a primary anesthetic for brain mapping of the cortical speech area. The asleep-awake-sleep technique provided adequate sedation and analgesia throughout the surgery and allowed the patient to complete the necessary neuropsychological tests. To our knowledge, ours is the first description of the use of dexmedetomidine in pediatric neurosurgery. © 2003 Lippincott Williams & Wilkins, Inc.