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High-Dose Methotrexate and Primary Central Nervous System Lymphoma

Fahey, Jean B.; DiMaggio, Carolyn

Journal of Neuroscience Nursing: April 2007 - Volume 39 - Issue 2 - p 83–88

Primary central nervous system lymphoma (PCNSL) is a rare disease that is managed differently from other primary brain tumors and other types of systemic lymphomas. The use of high-dose methotrexate (HD-MTX) has improved survival rates. This article describes the experience of a patient treated with HD-MTX and outlines the essential aspects of care for the bedside practitioner. An understanding of the diagnostic workup and principles of treatment can minimize complications and maximize patient function as nurses care for the unique physical and emotional needs of this population.

Questions or comments about this article may be directed to Jean B. Fahey, MSN RN CCRN CNRN APRN BC, is a neuroscience clinical nurse specialist at Massachusetts General Hospital, Boston, MA.

Carolyn DiMaggio, BSN RN, is a neuroscience and neuro-oncology staff nurse at Massachusetts General Hospital, Boston, MA.

© 2007 American Association of Neuroscience Nurses