Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

McGuinness Sandra D.; Krone, Ruth; Metz, Luanne M.
Journal of Neuroscience Nursing: February 2002
Articles: PDF Only


Cranberry cocktail has been reported to reduce bacteriuria and pyuria in elderly women and self-reported urinary tract infection (UTI) in young female undergraduates, but commercially prepared cranberry concentrate supplements have never been evaluated in multiple sclerosis (MS) patients with neurogenic bladder. The purpose of this study was to determine whether one 8,000-mg cranberry concentrate supplement daily could prevent UTI in MS participants with bladder symptoms. We conducted a double-blind, randomized, placebo-controlled longitudinal trial of cranberry supplement versus placebo with participants who have MS. After informed consent had been obtained from the participants, baseline data were collected and participants were randomized to receive either one cranberry supplement or placebo daily for 6 months. The sample consisted of 135 participants. In the cranberry group 34.6% of participants failed (i.e., developed a UTI) versus 32.4% in the control group (p = .849). Not all cranberry supplements have been found to contain proanthocyanidins, the active ingredient of cranberries. Because there is no way for the consumer to distinguish supplements that contain proanthocyanidins from those that do not, taking juice or whole cranberries may be preferable.

Questions or comments about this article may be directed to: Sandra McGuinness, MN MS, Multiple Sclerosis Clinic, AC137A, Foothills Medical Centre, 1403 29 Street, NW, Calgary, Alberta T2N 2T9 Canada, or by e-mail to She is a research program coordinator at the Multiple Sclerosis Clinic.

Ruth Krone, BN, was an outpatient nurse at the Multiple Sclerosis Clinic.

Luanne M. Metz, MD FRCPC, is the director of the Multiple Sclerosis Clinic.

© 2002 American Association of Neuroscience Nurses