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Acute Management of Optic Neuritis: An Evolving Paradigm

Horton, Lindsay, MD; Bennett, Jeffrey L., MD, PhD

Section Editor(s): Costello, Fiona MD, FRCP(C)

doi: 10.1097/WNO.0000000000000700
Disease of the Year: Multiple Sclerosis

Abstract: The current management of acute optic neuritis (ON) is focused on expediting visual recovery through the use of high-dose intravenous corticosteroids. The recent identification of specific autoantibodies associated with central nervous system inflammatory disorders has provided novel insights into immune targets and mechanisms that impact the prognosis, treatment, and recurrence of ON. Therefore, neurologists and ophthalmologists need to be aware of clinical, laboratory, and imaging findings that may provide important clues to the etiology of ON and the potential need for aggressive management. Moving forward, rapid and accurate diagnosis of inflammatory ON will likely be critical for implementing clinical care that optimizes short-term and long-term therapeutic outcomes.

Departments of Neurology (LH, JLB) and Ophthalmology (JLB), University of Colorado Denver, Aurora, Colorado; and Program in Neuroscience (JLB), University of Colorado Denver, Aurora, Colorado.

Address correspondence to Jeffrey L. Bennett, MD, PhD, Department of Neurology, University of Colorado Denver, 12700 E.19th Avenue, Box B-182, Aurora, CO 80045; E-mail:

The authors report no conflicts of interest.

© 2018 by North American Neuro-Ophthalmology Society