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Gage FH. Neurogenesis in the adult brain.

Givre, Syndee MD, PhD, Reviewer

Journal of Neuro-Ophthalmology: June 2003 - Volume 23 - Issue 2 - p 164
IN OTHER JOURNALS: Neuroscience Journals: I. Neurogenesis in the Adult Brain

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina

Editor's Note: This section contains brief reviews of articles that have appeared in other journals within the past six months. From a comprehensive list of clinical and scientific medical journals, each reviewer has selected about 30 titles and reviewed the most pertinent articles. The March and September issues include reviews from ophthalmology and medicine journals; the June and December issues include reviews from neuroclinical and neuroscience journals.

Gage FH. Neurogenesis in the adult brain.

J Neurosci 2002;22:612–3.

The Journal of Neuroscience, Volume 22, Number 3, contains a review on neurogenesis in the adult mammalian brain, including a fine introduction by Fred H. Gage and several authoritative papers.

Although neurogenesis is common in many adult vertebrates, neuroscience dogma has it that no new neurons are added to the mammalian CNS in adulthood. This dogma stemmed from early histologic studies showing a scarcity of mitotic figures and intermediate cell forms, from simple to more complex neurons, in adult brains. Furthermore, the intricacy of dendritic and axonal branching of neurons and the complexity of their interconnections made it difficult to conceive of how new neurons could functionally integrate into the mature brain. But about 40 years ago, evidence of new neurons in the adult brain began to accrue. After much initial skepticism, neurogenesis in adult mammals, including primates, is now accepted as fact. It occurs in the subventricular zone adjacent to the olfactory bulb and in the dentate gyrus; it may occur in other regions of the brain as well. Some of the papers from this review are summarized below.

© 2003 Lippincott Williams & Wilkins, Inc.