Central nervous system infiltration of Waldenström's macroglobulinemia is referred to as Bing–Neel Syndrome. We describe 2 patients whose clinical presentation was due to isolated involvement of the anterior visual pathways. The mechanism of visual failure in Bing–Neel Syndrome may involve both infiltrative and autoimmune processes.
Harvard University (MSH); University of Saskatchewan (EJA); Massachusetts Eye and Ear Infirmary (DMC, RCS); and Massachusetts General Hospital (FH), Boston, Massachusetts.
Address correspondence to Fred Hochberg, MD, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114.
The authors report no conflicts of interest.
All authors drafted and revised the manuscript for content. M. S. Hughes, D. M. Cestari, and F. Hochberg analyzed and interpreted data. E. J. Atkins, D. M. Cestari, R. C. Stacy, and F. Hochberg performed the clinical examinations.