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Bilateral Optic Disc Pits With Posterior Pituitary Ectopia

Horton, Jonathan C. MD, PhD; Barkovich, A. James MD

Section Editor(s): McCulley, Timothy J. MD

doi: 10.1097/WNO.0000000000000528
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Abstract: Posterior pituitary ectopia has been reported previously in association with optic nerve hypoplasia, as a variant of septo-optic dysplasia. We describe a 14-year-old boy with posterior pituitary ectopia and bilateral optic disc pits. He had hypopituitarism and a reduction in visual acuity to 20/40 in each eye, owing to loss of foveal ganglion cells. Optic pits and posterior pituitary ectopia may have occurred together in the same subject by chance, but the rarity of both conditions suggests a possible association.

Departments of Ophthalmology, Neurology, and Physiology (JCH), Beckman Vision Center, University of California San Francisco, San Francisco, California; and Department of Radiology (AJB), University of California San Francisco, San Francisco, California.

Address correspondence to Jonathan C. Horton, MD, PhD, 10 Koret Way, San Francisco, CA 94143; E-mail:

Supported by National Eye Institute Grant EY10217, EY 02162, and Research to Prevent Blindness.

The authors report no conflicts of interest.

© 2017 by North American Neuro-Ophthalmology Society