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Nonarteritic Anterior Ischemic Optic Neuropathy and Obstructive Sleep Apnea

Bilgin, Gorkem MD, FEBO; Koban, Yaran MD; Arnold, Anthony C. MD

doi: 10.1097/WNO.0b013e31828eecbd
Original Contribution
Japanese Abstract

Background: To evaluate the obstructive sleep apnea syndrome (OSAS) in patients with nonarteritic anterior ischemic optic neuropathy (NAION).

Methods: We recruited 27 patients with NAION and 27 age-matched and sex-matched controls who also were similar for systemic risk factors such as diabetes mellitus, hypertension, and hypercholesterolemia. All patients and controls underwent overnight polysomnography for the diagnosis of OSAS and calculation of apnea-hypopnea index (AHI).

Results: Patients and controls were statistically similar in terms of age, sex, gender, smoking, systemic risk factors, neck circumference, and body mass index. The subjects with AHI ≥ 20 were accepted as OSAS. Fifteen of 27 patients (55.6%) with NAION and 6 of 27 controls (22.2%) had OSAS (P < 0.05).

Conclusion: The prevalence of OSAS was higher in patients with NAION, and the difference between patient and control groups was statistically significant (P < 0.05). This result supports prior series suggesting the association between NAION and OSAS.

Jules Stein Eye Institute (GB, ACA), Neuro-Ophthalmology Division, University of California, Los Angeles, Los Angeles, California; and

Ophthalmology Division (YK), Bayburt State Hospital, Bayburt, Turkey.

Address correspondence to Gorkem Bilgin, MD, FEBO, Jules Stein Eye Institute Room 2-247; 100 Stein Plaza, Los Angeles, CA 90095-7005; E-mail:

The authors report no conflicts of interest.

© 2013 by North American Neuro-Ophthalmology Society