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Anterior Ischemic Optic Neuropathy and Activated Protein C Resistance: A Case Report and Review of the Literature

Worrall Bradford B. M.D.; Moazami, Golnaz M.D.; Odel, Jeffery G. M. D.; Behrens, Myles M. M.D.
Journal of Neuro-Ophthalmology: September 1997
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Nonarteritic anterior ischemic optic neuropathy (AION) is a well-described entity that is believed to be caused by abnormal anatomy of the optic disc and to be precipitated by several stressor-s or disease states. Activated protein C resistance (APCR) is a recently described mutation of factor V (FV) gene that renders FV resistant to cleavage by activated protein C. APCR predisposes to thrombotic events. The case of a 61-year-old woman with AION and activated protein C resistance is presented, and the management is discussed. We thoroughly review the literature on these two conditions. We propose that a prospective analysis of the potential role of APCR in some cases of AION is needed and suggest that physicians consider this and other prothombotic states when evaluating patients with AION.

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