EDITORIAL: PDF OnlyOphthalmic and Central Nervous System Complications following Intracarotid BCNU (Carmustine)GRIMSON, B. S. M.D.; MAHALEY, M. S. JR. M.D., Ph.D.; DUBEY, H. D. M.D.; DUDKA, LYNN R.N.Author Information From the Department of Ophthalmology and the Division of Neurosurgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina. Journal of Clinical Neuro-Ophthalmology: December 1981 - Volume 1 - Issue 4 - p 261-264 Free Abstract Infusion of BCNU (Carmustine) into the internal carotid artery is being investigated as a method of increasing the dosage of this chemotherapeutic agent to brain tumors within the supply of this vessel. We report a 28-year-old white male who developed both transient and permanent ophthalmic complications reflecting vascular injury within the distribution of the ophthalmic artery. Flotation of smaller arterial catheters up the internal carotid and beyond the ophthalmic artery prior to injection of chemotherapeutic agents may help avoid such ocular sequalae as chronic ocular ischemia and subsequent ocular neovascularization. © Williams & Wilkins 1981. All Rights Reserved.