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Villoglandular Adenocarcinoma In Situ of Intestinal Type of the Hymen: De Novo Origin from Squamous Mucosa?

Dubé, Valérie MD1; Lickrish, Gordon M. MD2; MacNeill, Karen Nicole MD1; Colgan, Terence J. MD1

Journal of Lower Genital Tract Disease: July 2006 - Volume 10 - Issue 3 - p 156-160

Abstract: Adenocarcinomas of the lower genital tract are rare diseases, and most of them arise from the Bartholin glands. Villoglandular adenocarcinoma of intestinal type is a very uncommon neoplasm of unknown origin with only few cases described on the vulva and in the vagina. It is characterized by villoglandular architecture, mucinous-type epithelium with intestinal differentiation (goblet cells), and direct apposition of the tumor with the surface epithelium. We report a case that developed on the hymen of a 64-year-old woman and discuss its possible origin as arising de novo from the squamous epithelium.

We report a case of villoglandular adenocarcinoma in situ of intestinal type of the hymen, an unusual neoplasm of unknown etiology, and discuss its possible histogenesis.

Departments of 1Pathology and 2Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, Ontario, Canada

Reprint request to: Terence J. Colgan, MD, Pathology and Laboratory Medicine, Suite 600, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada, M5G 1X5. E-mail:

©2006The American Society for Colposcopy and Cervical Pathology