Biomarkers for Cervical Cancer Prevention Programs: The Long and Winding Road From Discovery to Clinical Use Wentzensen, Nicolas; Silver, Michelle I. Wentzensen, Nicolas; Silver, Michelle I. Less Journal of Lower Genital Tract Disease. 20(3):191-194, July 2016. In Brief In Brief Favorite PDF Permissions In Brief: As new biomarkers are being developed or introduced to the market, it is important for clinicians to ask critical questions about the role of a biomarker in the screening program. Buy
Natural Antibodies to Human Papillomavirus 16 and Recurrence of Vulvar High-Grade Intraepithelial Neoplasia (VIN3) Madeleine, Margaret M.; Johnson, Lisa G.; Doody, David R.; More Madeleine, Margaret M.; Johnson, Lisa G.; Doody, David R.; Tipton, Elaine R.; Carter, Joseph J.; Galloway, Denise A. Less Journal of Lower Genital Tract Disease. 20(3):257-260, July 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions Go to Full Text of this Article In Brief: Recurrence of high-grade intraepithelial neoplasia of the vulva (VIN3) was less frequent among women with detectable human papillomavirus 16 antibodies. Go to Full Text of this Article Open
High-Grade Cervical Intraepithelial Neoplasia Detected by Colposcopy-Directed or Random Biopsy Relative to Age, Cytology, Human Papillomavirus 16, and Lesion Size Chen, Qing; Du, Hui; Pretorius, Robert G.; More Chen, Qing; Du, Hui; Pretorius, Robert G.; Wang, Chun; Yang, Bin; Wang, Guixiang; Tang, Jinlong; Belinson, Jerome L.; Wu, Ruifang Less Journal of Lower Genital Tract Disease. 20(3):207-212, July 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: P16 + CIN 2/3+ patients, detected by random biopsy, are older and less likely to have human papillomavirus 16. Buy
Biomarkers p16, Human Papillomavirus and p53 Predict Recurrence and Survival in Early Stage Squamous Cell Carcinoma of the Vulva Hay, Casey M.; Lachance, Jason A.; Lucas, F.L.; More Hay, Casey M.; Lachance, Jason A.; Lucas, F.L.; Smith, Kahsi A.; Jones, Michael A. Less Journal of Lower Genital Tract Disease. 20(3):252-256, July 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Biomarkers p16, human papillomavirus, and p53 predict recurrence and survival in early stage vulvar squamous cell carcinoma. Buy
p16 Staining of Cervical Biopsies May Decrease the Frequency of Unnecessary Loop Electrosurgical Excision Procedures de Sam Lazaro, Shireen; Newbill, Colin P.; Berlin, Michelle; More de Sam Lazaro, Shireen; Newbill, Colin P.; Berlin, Michelle; Morgan, Terry K. Less Journal of Lower Genital Tract Disease. 20(3):201-206, July 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: p16 staining of cervical biopsies may decrease the frequency of unnecessary loop electrosurgical excision procedures. Buy
p16 Immunohistochemistry in Colposcope-Directed and Random Cervical Biopsies of CIN2 and CIN3 Arvizo, Cynthia; Chen, Qing; Du, Hui; More Arvizo, Cynthia; Chen, Qing; Du, Hui; Wang, Chun; Tang, Jinlong; Yang, Bin; Pretorius, Robert G.; Wu, Ruifang; Belinson, Jerome Leslie Less Journal of Lower Genital Tract Disease. 20(3):197-200, July 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: p16 immunostainings of colposcope-directed and random (colposcope-undetectable) biopsies of CIN2 and CIN3 are similar. Buy
HPV-Associated Atypical Mitotic Figures in Squamous Intraepithelial Lesions of the Lower Female Genital Tract Scurry, James; Baskota, Swikrity Upadhyay Scurry, James; Baskota, Swikrity Upadhyay Less Journal of Lower Genital Tract Disease. 20(2):165-168, April 2016. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: HPV-associated atypical mitotic figures, rods, and dots of chromosomal material in addition to the main mitotic spindle are common in squamous intraepithelial lesions. Buy
Squamous Intraepithelial Lesions in Cervical Tissue Samples of Limited Adequacy and Insufficient for Grading as Low or High Grade: Outcome, Clinico-Pathological Correlates, and Predictive Role of p16INK4a and Ki67 Biomarker Staining Lee, Sandra; Sabourin, Jeanelle; Gage, Julia; More Lee, Sandra; Sabourin, Jeanelle; Gage, Julia; Franko, Angela; Nation, Jill G.; Duggan, Máire A. Less Journal of Lower Genital Tract Disease. 19(1):35-45, January 2015. Abstract Abstract In Brief In Brief Favorite PDF Permissions In Brief: Ungraded SIL frequency was 2%, and the outcome was HSIL+ in 41%. The referral Pap test and colposcopic impression correlated with the outcome, and staining with both biomarkers had a high negative predictive value. Buy
