Secondary Logo

Journal Logo

Institutional members access full text with Ovid®

Zebras in Foreskin Dermatopathology

A Review

Alhatem, Albert MD1; Patel, Nitin MD2; Lambert, W. Clark MD, PhD1,3; Heller, Debra S. MD1

Journal of Lower Genital Tract Disease: July 2019 - Volume 23 - Issue 3 - p 235–240
doi: 10.1097/LGT.0000000000000478

Objectives The aim of the study was to review uncommon foreskin dermatopathology conditions clinically and pathologically.

Methods A database search of PubMed and Google Scholar were extracted between March 1, 2009, and March 1, 2019, using the search terms “foreskin,” “prepuce,” “penis,” “pathology,” “dermatology,” and “rare.” The search was limited to “humans” and “dermatopathology.” Full article texts were reviewed. Reference lists were screened for additional articles. Patient details (diagnosis, dermatopathology, treatment, and follow-up if available) were extracted. We excluded articles written in the non-English language, unusual variants of common conditions, and cases of common dermatologic conditions.

Results A list of 369 articles was identified and another screening identified 30 articles for rare foreskin pathologies. Those are divided into categories based on the following etiologies: (a) benign, including congenital (e.g., aposthia), infectious (graft versus host disease and histoplasma), autoimmune (Crohn's disease and pyoderma gangrenosum), and benign neoplasms (neurofibroma, apocrine hidrocystoma, verruciform xanthoma, porokeratosis, penile cutaneous horn, localized amyloidosis) and (b) malignancies, including primary (myeloid sarcoma, basal cell carcinoma, Kaposi's sarcoma, mucosal-associated lymphoid tissue lymphoma), and metastasis.

Conclusions We reviewed and discussed unusual benign and malignant dermatopathology conditions that can affect the foreskin.

1Department of Pathology, Immunology, University Hospital and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ;

2Division of Urology, Department of Surgery, University Hospital, Rutgers New Jersey Medical School, Newark, NJ; and

3Department of Dermatology, University Hospital, Rutgers New Jersey Medical School, Newark, NJ

Reprint requests to: Albert Alhatem, MD, Pathology, Immunology, and Laboratory Medicine, Rutgers New Jersey Medical School, 150 Bergen St, E Level, Rm 163A, Newark, NJ, 07103. E-mail:

The authors have declared they have no conflicts of interest.

Online date: 30 5, 2019

Copyright © 2019 by the American Society for Colposcopy and Cervical Pathology