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Fact or Fiction? Adipose-Derived Stem Cells and Platelet-Rich Plasma for the Treatment of Vulvar Lichen Sclerosus

Eshtiaghi, Panteha, BS1; Sadownik, Leslie Ann, MD, MEd2,3

Journal of Lower Genital Tract Disease: January 2019 - Volume 23 - Issue 1 - p 65–70
doi: 10.1097/LGT.0000000000000440
Original Research Articles: Vulva and Vagina

Objective The aim of the study was to summarize and review the evidence for the efficacy and safety of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (LS).

Materials and Methods PubMed/MEDLINE, Ovid, Web of Science, and were searched from inception up to May 7, 2018.

Results Seven observational studies were identified, with a total of 98 patients. Both ADSCs and PRP were reported to improve symptoms, quality of life measures, as well as clinical and histological signs of vulvar LS. There is a strong risk of biased estimates of treatment effect.

Conclusions Current evidence is weak for ADSCs and/or PRP as treatment for vulvar LS. Further research is needed before recommending this therapy.

1Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;

2Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of British Columbia; and

3BC Centre for Vulvar Health, Vancouver, British Columbia, Canada

Reprint requests to: Leslie Ann Sadownik, MD, MEd, University of British Columbia, 6th Floor GLDHCC, 2775 Laurel St, Vancouver, British Columbia V5Z 1M9. E-mail:

The authors have declared they have no conflicts of interest.

Copyright © 2019 by the American Society for Colposcopy and Cervical Pathology