The aim of the study was to summarize and review the evidence for the efficacy and safety of adipose-derived stem cells (ADSCs) and platelet-rich plasma (PRP) for the treatment of vulvar lichen sclerosus (LS).
PubMed/MEDLINE, Ovid, Web of Science, and clinicaltrials.gov were searched from inception up to May 7, 2018.
Seven observational studies were identified, with a total of 98 patients. Both ADSCs and PRP were reported to improve symptoms, quality of life measures, as well as clinical and histological signs of vulvar LS. There is a strong risk of biased estimates of treatment effect.
Current evidence is weak for ADSCs and/or PRP as treatment for vulvar LS. Further research is needed before recommending this therapy.
1Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada;
2Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of British Columbia; and
3BC Centre for Vulvar Health, Vancouver, British Columbia, Canada
Reprint requests to: Leslie Ann Sadownik, MD, MEd, University of British Columbia, 6th Floor GLDHCC, 2775 Laurel St, Vancouver, British Columbia V5Z 1M9. E-mail: firstname.lastname@example.org
The authors have declared they have no conflicts of interest.