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High-Grade Squamous Intraepithelial Lesion Could Be Managed Conservatively in Women Up to 25 Years: Results From a Retrospective Cohort Study

Agramunt, Sílvia MD1; Checa, Miguel Ángel MD, PhD1; González-Comadrán, Mireia MD1; Larrazabal, Fernando MD1; Arbós, Alèxia MD1; Alameda, Francesc MD, PhD2; Mancebo, Gemma MD, PhD1; Carreras, Ramon MD, PhD1

Journal of Lower Genital Tract Disease: October 2013 - Volume 17 - Issue 4 - p 459–462
doi: 10.1097/LGT.0b013e3182838b7c
Original Articles

Objective The aim of this study was to compare histologic findings and clinical outcomes of women up to 25 years with a high-grade squamous intraepithelial lesion (HSIL) compared to women older than 25 years.

Materials and Methods Sixty-three women up to 25 years and 245 women older than 25 years with HSIL, diagnosed from June 1991 to September 2008, were examined and treated following the official Spanish guidelines. Colposcopic and histologic findings and needs for treatment were recorded, and patients were followed up for a minimum of 12 months.

Results A total of 308 patients were evaluated; 63.49% of women up to 25 years and 77.10% of women older than 25 years with HSIL had cervical intraepithelial neoplasia (CIN) 2+ histology (p = .04). Also, 74.60% of women up to 25 years and 99.24% of women older than 25 years underwent an excisional procedure (p < .001). No significant or clinical differences were found in the 1-year follow-up outcomes (82.54% vs 78.37% had normal results; p = ns).

Conclusions Women up to 25 years have less CIN 2+ histologic findings and less need for conization compared to older women. Our findings support the feasibility to design an adequate protocol for these younger women, which would be less aggressive and would, consequently, minimize obstetric long-term secondary effects.

High-grade squamous intraepithelial lesion in women up to 25 years can probably be managed less aggressively to avoid obstetric long-term secondary effects.

1Obstetrics and Gynecology and 2Pathology Departments, Hospital del Mar, Barcelona, Spain

Reprint requests to: Sílvia Agramunt, MD, Obstetrics and Gynecology Department, Hospital del Mar, Paseo Maritimo, 25. 08003 Barcelona, Spain. E-mail:

No financial support was received for this study.

The authors have declared they have no conflicts of interest.

Copyright © 2013 by the American Society for Colposcopy and Cervical Pathology