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Embryonal Rhabdomyosarcoma of the Uterine Cervix in Adults: A Case Report and Literature Review

Ditto, Antonino MD1; Martinelli, Fabio MD1; Carcangiu, Marialuisa MD2; Solima, Eugenio MD1; de Carrillo, Karla Jeanette Amaya MD1; Sanfilippo, Roberta MD3; Haeusler, Edward MD4; Raspagliesi, Francesco MD1

Journal of Lower Genital Tract Disease: October 2013 - Volume 17 - Issue 4 - p e12–e17
doi: 10.1097/LGT.0b013e31827a8b8c
Case Reports

Objective We report a case of cervical rhabdomyosarcoma in an adult and review of literature.

Materials and Methods A 44-year-old, premenopausal, white woman, complained of vaginal bleeding for 2 months. The gynecological examination showed a cervical polyp protruding from the vagina. The polyp was partially removed by polypectomy. Pathological examination was diagnostic for embryonal rhabdomyosarcoma—botryoid type—of the cervix. Radical class II hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and pelvic lymphadenectomy were performed. Adjuvant multidrug chemotherapy (vincristine, doxorubicin, ifosfamide, and etoposide) plus external beam radiotherapy were administered. Forty-six months after diagnosis, the patient is disease free.

Results Here, we report a new case and a literature review of a fairly rare cancer, rhabdomyosarcoma of the cervix in an adult. Pathological features and treatment with an aggressive multimodal approach (radical surgery followed by multidrug adjuvant chemotherapy and radiotherapy) are reported. Good treatment-tolerance and optimal results were achieved.

Conclusions Every effort should be done during both the diagnostic and therapeutic phase to offer these patients the best chance of survival. Further studies on best approach, chemotherapeutic protocols, and outcome in adults are warranted.

Cervical rhabdomyosarcoma deserves intensive diagnostic assessment and multimodal therapy.

Departments of 1Gynecologic Oncology, 2Pathology, 3Medical Oncology-Adult Sarcoma, and 4Anesthesiology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

Reprint requests to: Antonino Ditto, MD, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy. E-mail:

The authors have declared they have no conflicts of interest.

Copyright © 2013 by the American Society for Colposcopy and Cervical Pathology