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Late Recurrence of Aggressive Angiomyxoma of the Vulva

Kiran, Gurkan1; Yancar, Semih1; Sayar, Hamide2; Kiran, Hakan1; Coskun, Ayhan1; Arikan, Deniz Cemgil1

Journal of Lower Genital Tract Disease: January 2013 - Volume 17 - Issue 1 - p 85–87
doi: 10.1097/LGT.0b013e3182545d2f
Original Articles

Objective Aggressive angiomyxoma (AA) is found mainly in the pelvis and perineum, with a female-to-male ratio of approximately 6:1. Although it is a slow growing tumor, AA has a marked tendency to local recurrence with a low metastasis capacity. The study aimed to describe a case of vulvar angiomyxoma recurred almost 20 years after its initial surgery.

Materials and Methods We report the case of a 57-year-old gravida 5 para 4 woman with vulvar AA arising from the left labium majus, which recurred 20 years after initial surgery. There was a nontender, solid, mobile mass on the left vulva, which was 25 x 30 cm on physical examination. A pelvic computed tomographic scan showed a mass measuring 26 x 10 x 14 cm originating from left vulvar region, which has a fatty tissue density.

Result Under general anesthesia, total excision of the tumor was performed. Macroscopically, the tumor weighed 723 g and measured 33 x 20 x 10 cm. The histopathological examination of the specimen revealed a myxoid tumor with sparse infiltrates of spindle-shaped to stellate cells and vessels of varying sizes. The final histopathological diagnosis was AA.

Conclusions Aggressive angiomyxoma may form extremely large tumors, and recurrence is not rare even many years after primary surgery.

Aggressive angiomyxoma of the vulva may recur sometimes many years after the original diagnosis.

1Departments of Obstetrics and Gynecology and 2Pathology, School of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey

Reprint requests to: Gurkan Kiran, Kahramanmaras Sutcu Imam Universitesi Tip Fakultesi, Kadin Hastaliklari ve Dogum Anabilim Dali Yoruk Selim Mah Hastane Cad No: 32 46050 Kahramanmaras, Turkey. E-mail:

This case was presented as poster presentation at the 17th International Meeting of the European Society of Gynaecological Oncology September 11 to 14, 2011, at Milan, Italy.

The authors declare they have nothing to disclose.

©2013The American Society for Colposcopy and Cervical Pathology