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Lichen Sclerosus: A 5-Year Follow-Up After Topical, Subdermal, or Combined Therapy

Ventolini, Gary MD; Swenson, Krista M. MD; Galloway, Michael L. DO

Journal of Lower Genital Tract Disease: July 2012 - Volume 16 - Issue 3 - p 271–274
doi: 10.1097/LGT.0b013e31823da7e8
Original Articles

Objective The purpose of our study was to compare clinical data regarding patients with pruritic lichen sclerosus (LS) at moderate or severe stages using 2 different therapies with a 5-year follow-up.

Materials and Methods The study was approved by the institutional review board and was presented as a retrospective clinical data review of patients with pruritic biopsy diagnosis LS who underwent therapy at our university private practice from 2002 to 2005. We compared the results of a weekly topical application of high-potency steroid (HPS) with a combined HPS and monthly anesthetic/steroid subdermal injection (ASI). Outcomes were timed to achieve pruritus-free status, the number of symptomatic recurrences, and patient satisfaction with therapy.

Results Fifty-four patients were diagnosed with LS between 2002 and 2005. There were 13 patients who had mild-stage, 25 who had moderate-stage, and 16 who had severe-stage LS. Five-year follow-up data on 17 patients with moderate-stage LS and 14 patients with severe-stage LS were obtained. Time to pruritus free was 6 weeks with ASI and 19 weeks with HPS for moderate-stage LS (p = .04) and 9 weeks with ASI and 24 weeks with HPS for severe-stage LS (p = .03). Recurrences were more frequent on HPSfor moderate-stage LS (p = .04) but not significant with HPS for severe-stage LS (p = .15). Only ASI was successful at treating patients with recalcitrant pruritus.

Conclusions In our population, patients with symptomatic moderate-stage LS seem to have a more rapid and prolonged response to ASI than to HPS but are less satisfied with the injections.

Boonshoft School of Medicine, Wright State University, Dayton, OH

Reprint requests to: Gary Ventolini, MD, Boonshoft School of Medicine, Wright State University, Dayton, OH. E-mail:

©2012The American Society for Colposcopy and Cervical Pathology