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Gastrointestinal Stromal Tumor Arising in the Rectovaginal Septum

Vázquez, Julio PhD, MD1; Pérez-Peña, Mar MD2; González, Begoña MD3; Sánchez, Angel MD1

Journal of Lower Genital Tract Disease: April 2012 - Volume 16 - Issue 2 - p 158–161
doi: 10.1097/LGT.0b013e31823b52af
Case Reports

Objective To describe a rare case of gastrointestinal stromal tumor (GIST) outside the gastrointestinal tract and arising in the rectovaginal septum with literature review.

Case This study involved a 29-year-old woman, gravida 0, with a GIST presenting as an asymptomatic tumor in the rectovaginal septum. The tumor was excised locally, and the patient received imatinib as adjuvant therapy. She is free of disease 2 years after surgery.

Conclusions To our knowledge, only 5 cases of GIST presenting as rectovaginal mass have been reported previously. Local excision is the definitive treatment and the use of imatinib shows promising results. Mitotic activity, cellularity, and necrosis are the main prognostic factors. Long-term follow-up is necessary.

Different physicians involved in the evaluation of a mass arising in the rectovaginal septum should be alert of GIST as differential diagnosis, even in young women.

A mass arising in the rectovaginal septum should include gastrointestinal stromal tumor in the differential tract with an incidence on the order of 10 per million people year.

Departments of 1Obstetrics and Gynecology, 2Radiology, and 3Pathology, Álvarez-Buylla Hospital, Mieres, Spain

Reprint requests to: Julio Vázquez, PhD, MD, Servicio de Obstetricia y Ginecología, Hospital Álvarez Buylla, Carretera de Murias s/n, 33616 Mieres, Principado de Asturias, Spain. E-mail:

©2012The American Society for Colposcopy and Cervical Pathology