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Correlation of Atopobium vaginae Amount With Bacterial Vaginosis Markers

Marconi, Camila MSc1; Cruciani, Frederica MSc2; Vitali, Beatrice PhD2; Donders, Gilbert G.G. MD, PhD3,4,5

Journal of Lower Genital Tract Disease: April 2012 - Volume 16 - Issue 2 - p 127–132
doi: 10.1097/LGT.0b013e31823c79c4
Original Articles

Objective The purpose of this study was to test the correlation of the amount of Atopobium vaginae with the most commonly used markers for bacterial vaginosis (BV).

Materials and Methods We enrolled 103 nonpregnant and premenopausal women that were positive for BV by Amsel criteria and with a Nugent score higher than 3. All women were negative for yeast, Chlamydia trachomatis, Trichomonas vaginalis, and Neisseria gonorrhoeae. A. vaginae concentration was determined by quantitative polymerase chain reaction from samples of vaginal rinsings with 2 mL of sterile saline.

Results There was no difference in the median values of A. vaginae concentration when comparing samples with presence or absence of each individual Amsel criterion. In the case of a higher pH cutoff value of 4.9, greater amounts of this microorganism (p = .02) were found. In addition, correlation tests showed that A. vaginae concentration is positively correlated with pH (p < .001) and with Nugent scores (p = .003).

Conclusions The quantification of A. vaginae is useful for identification of the most severe cases of BV.

There is a positive correlation of the amount of Atopobium vaginae and both vaginal pH and bacterial vaginosis score.

1Department of Pathology, Botucatu Medical School, Sao Paulo State University, Botucatu, Sao Paulo, Brazil; 2Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Bologna, Bologna, Italy; 3Femicare Clinical Research for Women; 4Department of Obstetrics and Gynaecology, Regional Hospital H Hart, Tienen; and 5University Hospital Gasthuisberg, Leuven, Belgium

Reprint requests to: Gilbert G.G. Donders, MD, PhD, Femicare vzw, Gasthuismolenstraat 31, B-3300 Tienen, Belgium. E-mail:

None of the authors have a conflict of interest.

©2012The American Society for Colposcopy and Cervical Pathology